have a bleeding problem or a family history of a bleeding problem. Boehringer Ingelheim is one of the world's top 20 pharmaceutical companies. Ofev pregnancy and breastfeeding warnings. If you become pregnant or think you are pregnant while taking nintedanib, tell your doctor right away. If youre interested in finding an alternative to Ofev, talk with your doctor. Talk to your doctor about birth control methods that you can use during your treatment and for at least 3 months after your last dose of nintedanib. Non-receptor tyrosine kinases: Lck, Lyn, and Src kinases. Ofev contains the active drug nintedanib. Dosing & What To Expect - OFEV (nintedanib) Capsules Viruses. Would you like email updates of new search results? It is not known if nintedanib passes into your breast milk. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. -, Ley B, Collard HR, King TE., Jr. Clinical course and prediction of survival in idiopathic pulmonary fibrosis. Its important to have prompt diarrhea management if you have this side effect. However, be sure to take the dosage your doctor prescribes for you. If your diarrhea doesnt get better in a few days or gets worse, see your doctor right away. antifibrotic; idiopathic pulmonary fibrosis; interstitial lung disease; nintedanib. Nintedanib Oral: Uses, Side Effects, Interactions, Pictures - WebMD If you are pregnant or planning a pregnancy: If you are breastfeeding or are planning to breastfeed: Ofev Inactive ingredients: Ofev is an effective treatment for slowing lung function decline in people with interstitial lung disease associated with systemic sclerosis. Before you take this medicine, tell your doctor about all of your medical conditions, including if you: The usual recommended dosage of nintedanib is a 150 mg capsule swallowed whole with liquid,taken twice daily approximately 12 hours apart. If you and your doctor determine that Ofev is safe and effective for you, youll likely take it long term. It can cause symptoms such as: Youll likely have other symptoms with systemic sclerosis as well. To read more about this, see the Common questions about Ofev section above. Multi-Targeting Approach in Selection of Potential Molecule for COVID-19 Treatment. It allows a doctor to examine the inside of the lungs, which can help them to diagnose the cause, Idiopathic pulmonary fibrosis is a chronic, progressive condition that affects the lungs. Velagacherla V, Suresh A, Mehta CH, Nayak UY, Nayak Y. -, Raghu G, Collard HR, Egan JJ, et al. Everything you need to know about mesothelioma: Esbriet, Actemra, tocilizumab, pirfenidone, nintedanib, Actimmune, interferon gamma-1b. With most types of interstitial lung disease, the fibrosis in your lungs gets worse over time. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. and transmitted securely. Continue reading, Experts are not sure exactly why Ofev causes diarrhea but research has suggested that it may be due to receptor inhibition (Ofev is a triple receptor [PDGFR, VEGFR, or FGFR] tyrosine kinase inhibitor) or via a direct inflammatory action on intestinal mucosa by Ofev or its breakdown products. In addition, trials often exclude concomitant emphysema on chest imaging, not an uncommon finding in clinical practice. To use the sharing features on this page, please enable JavaScript. Treatment can help relieve, A bronchoscopy is a safe, relatively quick procedure. Specifically, Ofev is FDA-approved to treat: Ofev contains the active drug nintedanib. Nintedanib inhibits a variety of receptor and nonreceptor tyrosine kinases these are signaling proteins that work as an ON/OFF switch in many cell-to-cell communications. Cigarette smoking may decrease the effectiveness of this medication. The interstitium is a network of tissue that runs throughout your lungs and supports the alveoli (tiny air sacs). Talk with your doctor about using a form of birth control that isnt affected by vomiting or diarrhea, such as an injection or implant. This causes your symptoms and lung function to worsen as the condition progresses. As with most drugs, some people can have an allergic reaction after taking Ofev. Ofev comes as a capsule that you take by mouth. Call your doctor right away if you have serious side effects. Follow all directions on your prescription label and read all medication guides or instruction sheets. With autoimmune conditions, your immune system mistakenly attacks your bodys own healthy cells. Some supplements may help with the symptoms of lung disease. Nintedanib may cause serious side effects, including: The most common side effects of nintedanib are: These are not all the possible side effects of nintedanib. How does nintedanib work? The safety and tolerability of nintedanib in the treatment of idiopathic pulmonary fibrosis. Other medical problems can occur when your brain, heart, and other organs do not get enough oxygen. The current stance of the Food and Drug Administration (FDA) is to avoid using expired medications. Copyright 1996-2023 Cerner Multum, Inc. The scar tissue thickens and becomes stiff or thick over time, which can make it harder for your lungs to work. If you experience side effects from Ofev such as diarrhea, nausea, and vomiting it may help to avoid the following foods and drinks: It takes 6 to 12 weeks for Ofev to start working, which has been measured in clinical trials of people with interstitial lung disease as less of a change in lung capacity (as measured by an FVC or Forced Vital Capacity) after at least 6 weeks in those prescribed Ofev. Your doctor will order certain lab tests before and during your treatment to check your body's response to nintedanib. Lysosomes as a Target of Anticancer Therapy. To help make sure that you dont miss a dose, try using a medication reminder. Ofev is an effective treatment for idiopathic pulmonary fibrosis. For more information about taking Ofev during pregnancy, see the Ofev and pregnancy section above. New study results provide evidence that Ofev (nintedanib) slows